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Remise de la médaille Chevreul 2018 au Dr Thierry Durand

SFEL Chevreul Medal Lecture:
When Chemist Synthesize Oxylipins and share them with Biologists, Physiologists, Clinicians and Lipidomists: 25 Years of Happiness
Thierry Durand

Institut des Biomolécules Max Mousseron, IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier (France). Thierry.Durand@umontpellier.fr

Polyunsaturated fatty acids (PUFAs) include two series of fatty acids: omega-6 and omega-3 series, and possess amphipathic properties: hydrophilic head and hydrophobic tail maintaining cell-membrane fluidity, inhibiting inflammatory processes, decreasing secretion of proinflammatory cytokines by monocytes/macrophages, decreasing susceptibility to ventricular rhythm disorders of the heart, improving functions of vascular endothelial cells, inhibiting blood platelet aggregation and decreasing triglyceride synthesis in the liver. These PUFAs, because of the number of skip dienes are prone to be oxidized by enzymatic and non enzymatic pathways, leading to oxygenated metabolites (prostaglandins, leukotriens, resolvins, protectins, and phyto-, iso-, neuroprostanes and phyto-, iso-, neurofurans, respectively).
Chemical synthesis of those oxygenated metabolites are of great interest. In this lecture, I will present briefly the chemical strategies we have developed since the last 25 years, to reach those cyclic and non cyclic oxygenated metabolites of PUFAs and their use as bioactive lipids, and as standards in lipidomics. Thanks to our collaborators for their wonderful works they have performed using our synthetic oxylipins.